EBM+ is interested in using evidence of mechanisms in conjunction with evidence of correlation to help evaluate causal claims in medicine. One objection to this idea is that it is hard to do this in practice.
It’s hard but it’s not impossible …
Several members of the EBM+ team have been working on a methodological handbook for those interested in taking evidence of mechanisms into account. Here’s a preliminary draft.
Please take a look and send me your comments! They’ll help shape version 1, which will hopefully appear on this website later this year.